Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC QTX125 trifluoroacetate | 2989537-78-0 | 99.9% | 100 MG
QTX125 TFA is the trifluoroacetate salt of QTX125, a potent and highly selective histone deacetylase 6 (HDAC6) inhibitor with reported antitumor activity. Supplied as an off-white to gray solid for research use, it is available in multiple pack sizes and should be stored sealed and protected from moisture.
- Potent and selective HDAC6 inhibitor
- High reported purity and chemical stability
- Provided as a trifluoroacetate salt for improved handling
- Suitable for in vitro and preclinical research applications
- Store sealed, away from moisture; follow cold storage recommendations
TARGETMOL CHEMICALS INC Dermorphin TFA 2MG
Also available in 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Dermorphin TFA is a new class of opioids-like peptides Purity 100%
TARGETMOL CHEMICALS INC Atecegatran TFA 1MG
Also available in 5 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Atecegatran TFA is often used as an anticoagulant and can be used to treat cardiovascular disease. Purity 98.5%
Medchemexpress LLC 3-amino-4-(3-hexylphenylamino)-4-oxobutyl phosphonic acid | 909725-62-8 | 98.2% | 456.39 g/mol | C18H28F3N2O6P | 1 ML
W146 TFA is the trifluoroacetic acid salt of W146, a selective antagonist of the sphingosine-1-phosphate receptor 1 (S1PR1). It is supplied as a ready-to-use 10 mM solution in DMSO and as solid material for research applications, and is used in in vitro pharmacology and signaling studies to probe S1PR1-mediated pathways.
- Selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1).
- Reported EC50 of 398 nM.
- Supplied as 10 mM solution in DMSO (1 mL) and in multiple solid masses.
- Chemical identifiers: CAS 909725-62-8, formula C18H28F3N2O6P, MW 456.39 g/mol.
- Intended for research use only; not for human or clinical use.
Medchemexpress LLC Homoglutathione trifluoroacetate | 435.37 | C13H20F3N3O8S | 25mg
Homoglutathione (TFA) is a biological molecule
Medchemexpress LLC Trifluoroacetic acid-13C sodium | 286425-32-9 | 98.0% | 137.00 g/mol | C13CF3NaO2 | 1mg
Trifluoroacetic acid-13C sodium is the 13C labeled isotope of Trifluoroacetic acid-13C (sodium) (HY-W754811)[1]
Medchemexpress LLC Jbsnf-000028 tfa | C13H14F3N3O2 | 25 MG
JBSNF-000028 TFA is an orally active small molecule inhibitor of the tricyclic nicotinamide N-methyltransferase (NNMT). It reduces endogenous MNA levels in U2OS osteosarcoma cells and shows significant anti-obesity and anti-diabetic activities in the diet-induced obesity (DIO) model. This compound is suitable for research into metabolic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease.
- Inhibits NNMT activity in U2OS cells with an EC50 of 2.5 μM.
- Shows no cytotoxicity against HepG2 cells at concentrations of 10-100 μM.
- Improves glucose and lipid handling in diet-induced obese mice.
- Enhances glucose tolerance in NNMT knockout mice with diet-induced obesity.
Medchemexpress LLC JPS014 TFA | 98.12% | C48H60F3N7O9S | 25 MG
JPS014 TFA is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC). It degrades class I histone deacetylase (HDAC) and is a potent HDAC1/2 degrader. This degradation correlates with a greater number of total differentially expressed genes and enhanced apoptosis in HCT116 cells.
- Benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC)
- Degrades class I histone deacetylase (HDAC)
- Potent HDAC1/2 degrader
- Correlates with greater total differentially expressed genes
- Enhances apoptosis in HCT116 cells