Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC BIM 23042 trifluoroacetate | 00-00-0 | 96.2% | 1192.45 g/mol (free base) | C63H73N11O9S2.xC2HF3O2 | 5 MG
BIM 23042 TFA is a somatostatin-like octapeptide analogue that functions as a selective antagonist of the neuromedin B receptor (NMB-R/BB1). Supplied as the trifluoroacetate (TFA) salt at high purity, it is intended for research use in receptor pharmacology and related biochemical assays.
- Selective antagonist of neuromedin B receptor (BB1).
- TFA salt form for improved handling and stability.
- High purity suitable for receptor pharmacology and calcium mobilization assays.
- Supplied as a small, lyophilized quantity for laboratory research use.
- Molecular weight and elemental composition available in the product documentation.
Medchemexpress LLC Homoglutathione TFA | 95.0% | 435.37 | C13H20F3N3O8S | 5mg
Homoglutathione (TFA) is a biological molecule
![Medchemexpress LLC Carbamic acid, N-methyl-N-[2-(methylamino)ethyl] ester, 2,2,2-trifluoroacetate | 1224601-17-5 | MFCD01938808 | 98.1% | 620.57 g/mol | C29H31F3N4O8 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000201969.png-250.jpg)
Medchemexpress LLC Carbamic acid, N-methyl-N-[2-(methylamino)ethyl] ester, 2,2,2-trifluoroacetate | 1224601-17-5 | MFCD01938808 | 98.1% | 620.57 g/mol | C29H31F3N4O8 | 1 ML
SN-38-CO-DMEDA TFA is a research-grade carbamate intermediate (trifluoroacetate salt) used in the synthesis of antibody-drug conjugates such as LND1035. Supplied as a 10 mM solution in DMSO (1 mL), it has CAS number 1224601-17-5, chemical formula C29H31F3N4O8, molecular weight 620.57 g/mol, and reported purity 98.07%.
- 10 mM solution in DMSO, 1 mL
- Intended for use as a chemical synthesis intermediate
- Reported purity 98.07%
- CAS number 1224601-17-5
- Available as solid quantities in multiple sizes
Apexbio Technology LLC 2X hyperfusion plus master mix (With dye) 10X1ml
Our 2X Hyperfusion Plus Master Mix (With dye) product offers high fidelity strong amplification performance and faster extension speed simultaneously making it suitable for most PCR applications Hyperfusion Plus DNA Polymerase is created by fusing a Pyrococcus-like proofreading polymerase with a DNA binding domain providing increased fidelity and speed Hyperfusion Plus DNA Polymerase owns high fidelity 50 times lower error rate than Taq DNA Polymerase and 6 times lower error compared to Pyrococcus Furious DNA Polymerase Experimental results demonstrate that our Hyperfusion Plus polymerase can amplify genome fragments as long as 20 1 kb 2X Hyperfusion plus master mix (With dye) is a ready-to-use 2 premix solution containing polymerase dNTPs an already optimized buffer system and dye Our mix is ideal for any detection and the PCR product can be directly electrophoresed after the amplification without the need to add a loading buffer
Apexbio Technology LLC 10 mM dNTP Mixture 5x1ml
10 mM dNTP (2 -deoxynucleoside 5 -triphosphate) Mixture is an equimolar premixed aqueous solution containing four nucleotides (dATP dCTP dGTP and dTTP) each at a concentration of 10 mM The product is prepared as an aqueous solution titrated with NaOH to a neutral pH of 7 0
